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논문분류	춘계학술대회 초록집
제목	Cyclohexylalanine-Containing -Helical Amphipathic Peptides Targets Cardiolipin, Rescuing Mitochondrial Dysfunction in Kidney Injury
저자	Gwangsu Shin
출판정보	2025; 2025(1):
키워드	Mitochondrial dysfunction, cardiolipin, cristae structure, CAMP3013, ROS
초록	Mitochondrial dysfunction is linked to degenerative diseases, resulting from cardiolipin (CL)-induced disruption of cristae structure in the inner mitochondrial membrane (IMM); therefore, preserving cristae and preventing CL remodeling offer effective strategies to maintain mitochondrial function. To identify reactive oxygen species (ROS)-blocking agents against mitochondrial dysfunction, a library of cyclohexylamine-containing cell-penetrating α-helical amphipathic “bundle” peptides were screened. CMP3013 is selectively bound to abnormal mitochondria, preserving the cristae structure impaired by mitochondria-damaging agents. With a stronger affinity for CL compared with other IMM lipid components, CMP3013 exhibited high selectivity. Consequently, it protected cristae, reduced ROS production, and enhanced adenosine triphosphate (ATP) generation. In mouse models of acute kidney injury, a 1 mg/kg dose of CMP3013 demonstrated remarkable efficacy, highlighting its potential as a therapeutic agent for mitochondrial dysfunction-related disorders CMP3013 represents a promising agent for mitigating mitochondrial dysfunction and associated diseases.
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