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논문분류	춘계학술대회 초록집
제목	Analysis of Clinical Outcomes According to Early Graft Dysfunction in Deceased Kidney Transplantation: Multicenter Cohort Study
저자	Suyeon Hong
출판정보	2025; 2025(1):
키워드	Immediate graft function, Slow graft function, Delayed graft function, Deceased donor kidney transplant
초록	Slow graft function (SGF) is defined as failure of attainment of an absolute level of Cr by a given postoperative day (POD), Cr ≥2.5 on POD7 or Cr reduction ratio of <30% between POD1 and POD2. Delayed graft function (DGF) is defined as the need for dialysis during the first week after transplantation. Our study aims to evaluate the clinical long-term outcomes of SGF and DGF compared with immediate graft function (IGF). This was a Retrospective cohort analysis, time period between October 1996 to August 2022 with minimum follow up –1 year. Total DDKT done in this time period was 846. They were divided into 3 groups – IGF, SGF and DGF. Out of total renal transplants 65.6% (555) patients had IGF, 13.24% (112) patients had DGF and 21.16% (179) patients had SGF. Death censored graft survival at end of 5 year was 93.5% in IGF, 89.1% in SGF (p= 0.036) and 84.3% in DGF (p=0.003). Cumulative patient survival at end of 5 year was 95.1% in IGF, 94.6% in SGF (p=0.939), and 89.7% in DGF group(p=0.034). Acute rejection episodes were more prevalent in DGF group (31.4%), p=0.024, than SGF (20.2%) and IGF group (14.3%). SGF and DGF was associated with comparable increases in risk of graft failure compared to IGF (hazard ratio (HR) 1.56, 95% confidence intervals (CI) 1.02-2.18 for SGF and HR 2.20, CI 1.27-3.81 for DGF); For mortality, outcomes for SGF were similarly to IGF, both SGF and IGF were associated with lower risk relative to DGF (HR 0.58, CI 0.40-0.96 for SGF). In conclusion, SGF may be a marker for graft failure but not for mortality. SGF appear to represent an intermediate phenotype differ from IGF and DGF.
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