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논문분류	춘계학술대회 초록집
제목	Advanced Approach in Evaluation of the Risk Groups in Children with Type 1 Diabetes and Subclinical Diabetic Nephropathy
저자	Ievgeniia Burlaka
출판정보	2026; 2026(1):
키워드	children, Type 1 diabetes, Diabetic nephropathy, KIM-1, risk groups
초록	Objectives: To stratify children with T1D according to the risk of developing and progressing of DN using cluster analysis of clinical and biochemical parameters. Methods: Study included 60 children, 30 with T1D without signs of DN, and 30 with early DN. The main parameters for cluster analysis were duration of T1D, glomerular filtration rate (GFR), level of microalbuminuria (MAU), frequency of episodes of diabetic ketoacidosis (DKA) and kidney injury molecule (KIM-1) level. Results: Three clusters with different risk profiles were identified. The risk group for developing DN in T1D group of children demonstrated a moderate T1D duration, occasional MAU and DKA episodes, and a slight increase in the level of KIM-1. The risk group for progression of DN, in DN group, is manifested by a long T1D duration, pronounced MAU, frequent DKA, increased GFR, and a significantly increased concentration of KIM-1. Conclusion: The use of cluster analysis allows us to distinguish the risk group for DN in T1D group of children and the risk group for DN progression in DN group. Determination of the level of KIM-1 in urine, a biomarker of tubular damage, opens further prospects for targeted intervention before the formation of clinically significant DN.
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