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논문분류	춘계학술대회 초록집
제목	Premature Neutrophil Aging in End-Stage Renal Disease: Mechanistic Insights Into Uremic Toxin-Induced Immune Dysfunction
저자	Kritsanawan Sae-Khow
출판정보	2026; 2026(1):
키워드	Neutrophils, End-stage renal disease, Aging, Immune suppression
초록	Objectives: In addition to uremic toxin accumulation, neutrophil dysfunctions are a form of immune suppression in patients with End-stage renal disease (ESRD). However, data on this are limited. This study aimed to explore the mechanisms of neutrophil dysfunctions in ESRD associated with premature aging, largely driven by uremic toxins. Methods: Neutrophils were isolated from patients and healthy controls using density gradient centrifugation. Flow cytometry was used to identify aged neutrophils by expression of surface markers (CD16high CD62Llow CD184high).Neutrophil effector functions, both at baseline and after stimulation with phorbol myristate acetate (PMA) or lipopolysaccharide (LPS). In vitro experiments were conducted by incubating neutrophils with plasma collected before and after hemodialysis (HD). Results: In ESRD, neutrophils exhibited features of aging, associated with profound functional defects. Less prominent chemotaxis and phagocytosis and an increase in ROS production at the baseline were observed in ESRD neutrophils. Upon PMA or LPS stimulation, neutrophil effector functions in ESRD also remained significantly attenuated. In vitro exposure to pre-hemodialysis plasma, characterized by a high burden of uremic toxins, markedly induced premature neutrophil aging and enhanced ROS production, whereas post-hemodialysis plasma exerted a lesser effect. Conclusion: Uremic toxin accumulation promotes premature neutrophil aging, contributing to immunesenescence in ESRD. These findings provide mechanistic insight into immune suppression and highlight uremic toxin driven premature immune aging as a potential therapeutic target.
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