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논문분류	춘계학술대회 초록집
제목	Long-Term Renal and Cardiovascular Outcomes in Children with Congenital Anomalies of the Kidney and Urinary Tract (CAKUT): A Real-World Cohort Study
저자	Sajjad Ahmed Khan
출판정보	2026; 2026(1):
키워드	CAKUT, pediatric chronic kidney disease, cardiovascular outcomes, Renal outcomes
초록	Objectives: To evaluate long-term Renal and Cardiovascular outcomes in patients with CAKUT using TriNetX database. Methods: A retrospective cohort study was conducted using the TriNetX Research Network. Children aged ≤18 years with CAKUT (ICD-10 codes Q60-6Q4) were compared with pediatric controls undergoing routine health examinations without congenital urinary anomalies. The index event was the first qualifying diagnosis. Outcomes were assessed from 1 day after the index event. Outcomes analysis was done using risks, risk ratios (RR), odds ratios (OR), hazard ratios (HR), and Kaplan–Meier survival analyses. Results: After propensity score matching, 176,557 children were included in each cohort. Compared with matched controls, children with CAKUT had significantly higher risks of CKD stages 1–5 (8.7% vs 0.4%; RR 24.12; HR 29.25; p<0.001), end-stage renal disease (1.8% vs 0.1%; RR 17.83; HR 20.36; p<0.001), acute kidney injury (3.3% vs 0.7%; RR 4.92; HR 5.78; p<0.001), and dialysis dependence (1.1% vs 0.1%; RR 11.24; HR 12.86; p<0.001). Cardiovascular outcomes were also significantly increased, including hypertension (7.0% vs 2.1%; RR 3.31; HR 3.66; p<0.001), myocardial infarction (0.12% vs 0.04%; RR 2.82; HR 2.74; p<0.001), heart failure (0.34% vs 0.13%; RR 2.71; HR 2.89; p<0.001), cerebral infarction (0.38% vs 0.27%; RR 1.40; HR 1.44; p<0.001), and atherosclerosis (0.19% vs 0.04%; RR 4.91; HR 5.22; p<0.001), while peripheral vascular disease did not differ significantly between cohorts. Conclusion: CAKUT is associated with poor long-term renal and cardiovascular outcomes emphasizing the needs of long-term cardiorenal surveillance.
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