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논문분류	춘계학술대회 초록집
제목	Impact of Renal Function on Erythrocyte Membrane Fatty Acid Composition and Metabolic Enzyme Activities: A Retrospective Pooled Analysis
저자	Jin Kyeong Kim
출판정보	2026; 2026(1):
키워드	oleic acid, linoleic acid, chronic kidney disease, fatty acid, omega-3
초록	Objectives: Patients with chronic kidney disease (CKD) remain at high cardiovascular risk despite optimal management of traditional risk factors. Alterations in erythrocyte membrane fatty acid (FA) composition, particularly elevated oleic acid, have been associated with adverse cardiovascular outcomes. We aimed to evaluate the impact of renal function on erythrocyte membrane FA composition and estimated activities of FA metabolic enzymes. Methods: We performed a retrospective pooled analysis of six single-center studies (2015–2023). A total of 282 participants were included: 33 healthy controls, 131 patients with CKD, and 118 patients with end-stage renal disease (ESRD) on maintenance dialysis. Erythrocyte membrane FA composition was analyzed using gas chromatography. Enzyme activities were estimated by product-to-substrate ratios, including SCD16, SCD18, Δ6-desaturase, Δ5-desaturase, and ELOVL5. Associations between glomerular filtration rate (GFR) and FA composition were assessed using correlation and multivariate regression analyses. Results: ESRD patients exhibited significantly higher levels of saturated and monounsaturated FAs, including oleic acid, and lower levels of polyunsaturated FAs, omega-6 (including linoleic acid), omega-3 (including EPA and DHA), and omega-3 index compared to controls (P <0.001). The omega-6/omega-3 ratio was highest in ESRD. SCD16, SCD18, and Δ6-desaturase activities were reduced, whereas ELOVL5 activity was increased in CKD and ESRD groups (P <0.001). GFR was negatively associated with oleic acid (r = –0.344) and positively associated with linoleic acid (r = 0.411) (both P <0.001). In multivariate analysis, GFR independently predicted oleic acid levels (β = –0.350, P <0.001). Conclusion: Declining renal function is associated with significant alterations in erythrocyte membrane FA composition, likely mediated by changes in desaturase and elongase activities. Nutritional strategies targeting linoleic acid and omega-3 FAs may help correct FA imbalance in CKD.
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