대한신장학회

논문분류	춘계학술대회 초록집
제목	Association of Longitudinal Body Roundness Index Trajectories with Incident Chronic Kidney Disease in a Community-Based Korean Cohort
저자	Heewon Park
출판정보	2026; 2026(1):
키워드	Body roundness index, Chronic kidney disease, Trajectory analysis
초록	Objectives: Obesity is a major risk factor for chronic kidney disease (CKD), but cross-sectional measures may not capture dynamic adiposity changes. The body roundness index (BRI) reflects body fat distribution and visceral adiposity, yet its longitudinal association with CKD remains unclear. We investigated the relationship between BRI trajectories and incident CKD in a community-based Korean cohort. Methods: This prospective cohort study included participants from the Korean Genome and Epidemiology Study (KoGES) Ansan–Ansung cohort (2001–2020) with baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m² and at least three repeated measurements. BRI trajectories were identified using group-based trajectory modeling, and participants were classified according to longitudinal BRI patterns. The primary outcome was incident CKD, defined as eGFR <60 mL/min/1.73 m². Cumulative CKD incidence was compared using Kaplan–Meier analysis and the log-rank test, with multivariable adjustment for demographic and clinical covariates. Results: A total of 6,273 participants were included, and two distinct BRI trajectory groups were identified: a low-risk group (n=5,526) with stable, lower BRI levels and a high-risk group (n=747) with persistently elevated and increasing BRI levels. At baseline, the high-risk group was older, more frequently female, and had lower socioeconomic status, higher prevalence of hypertension and diabetes, higher BMI, waist circumference, and blood pressure, and lower baseline kidney function (mean eGFR 93.88 vs. 97.10 mL/min/1.73 m², p<0.001). During follow-up, the high-risk trajectory group showed a significantly higher cumulative incidence of CKD (log-rank p<0.001) and a steeper decline in eGFR. The association remained significant after multivariable adjustment. Conclusion: Obesity is a major risk factor for chronic kidney disease (CKD), but cross-sectional measures may not capture dynamic adiposity changes. The body roundness index (BRI) reflects body fat distribution and visceral adiposity, yet its longitudinal association with CKD remains unclear. We investigated the relationship between BRI trajectories and incident CKD in a community-based Korean cohort.
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