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논문분류	춘계학술대회 초록집
제목	Omega-3 Fatty Acids Attenuate Renal Myostatin Expression and Restore Mitochondrial Homeostasis Under Uremic Conditions
저자	Hye Jung Lee
출판정보	2026; 2026(1):
키워드	Chronic Kidney Disease, Mitochondrial Dysfunction, Myostatin, Omega-3 fatty acid, Uremia
초록	Objectives: While myostatin is a known mediator of systemic inflammation and muscle wasting, its expression in the kidney under uremic conditions remains poorly studied. This study investigated the effects of omega-3 fatty acids (FAs) on renal myostatin expression and mitochondrial homeostasis in a uremic model. Methods: Chronic kidney disease(CKD) was induced in male Sprague-Dawley rats using a 0.75% adenine and 2.5% protein diet for three weeks, followed by random allocation into three groups: normal control, adenine control (treated with saline and cholecalciferol 3000 IU/kg/week), and omega-3 FA group (300 mg/kg/day with cholecalciferol) for two additional weeks. Indoxyl sulfate (IS)-exposed HK-2 cells were used as an in vitro uremic model with or without omega-3 FAs. Renal myostatin expression, and mitochondrial markers were assessed by Western blotting. Mitochondrial ultrastructure was evaluated by transmission electron microscopy. Results: Adenine-induced uremia significantly increased serum creatinine levels, which were partially ameliorated by omega-3 FAs. Renal myostatin expression was markedly upregulated in both adenine-treated rats and IS-stimulated HK-2 cells. However, omega-3 FA supplementation significantly attenuates these effects. Uremia impaired mitochondrial homeostasis, characterized by decreased PGC-1α (biogenesis marker) and increased Drp1 (fission protein). Omega-3 FAs essentially reversed the uremia-induced upregulation of mitophagy and inflammatory markers. Notably, omega-3 FAs attenuated mitochondrial DNA depletion and preserved mitochondrial cristae integrity, as observed by TEM. Conclusion: These findings demonstrate that omega-3 FAs suppress renal myostatin expression and ameliorate mitochondrial dysfunction under uremic conditions. Our results suggest that omega-3 FAs may serve as a potent therapeutic strategy for preserving mitochondrial homeostasis in patients with CKD.
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