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논문분류	춘계학술대회 초록집
제목	Novel Gold Nanoparticle-Based Colorimetric Biosensor for Sensitive Detection of Creatinine: A Potential Tool for Early Diagnosis of Chronic Kidney Disease
저자	Girish Deokar
출판정보	2026; 2026(1):
키워드	Colorimetric sensor, gold nanoparticles, Creatinine detection, Kidney function biomarker, Chronic kidney disease (CKD)
초록	Objectives: To develop a novel, selective, and sensitive colorimetric sensor using biosynthesized gold nanoparticles (AuNPs) for the detection of creatinine, a key biomarker for early diagnosis and monitoring of kidney function and related renal diseases. Methods: Gold nanoparticles were synthesized via a green method. Characterization was performed using spectroscopic and microscopic techniques. TEM analysis revealed an average particle size of 9.6 nm, while UV–Vis spectroscopy showed an absorbance maximum at 538 nm. A colorimetric sensor was designed based on AuNPs, utilizing synergistic coordination between adenosine, creatinine, and Ag⁺ ions on the nanoparticle surface. The sensor was tested with artificial urine and serum samples to evaluate selectivity and sensitivity. Results: The AuNP-based sensor exhibited excellent selectivity for creatinine in the presence of adenosine and Ag⁺ ions. A visible color change in the colloidal solution indicated the presence of creatinine.The limit of detection (LOD) was calculated as 14.6 nM using standard deviation values. The sensor demonstrated promising sensitivity and selectivity in artificial urine and serum samples. Conclusion: The biosynthesized gold nanoparticle-based colorimetric sensor provides a simple, visible, and highly sensitive method for creatinine detection. This approach shows strong potential for early diagnosis and monitoring of chronic kidney disease. Further validation with real urine and serum samples is required to confirm clinical applicability.
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