대한신장학회

논문분류	춘계학술대회 초록집
제목	Hydration Volume-to-Weight Ratio for Predicting The Risk of Contrast Induced Acute Kidney Injury in Patient Undergoing Cardiac Interventions: A Systematic Review and Meta-Analysis of Prospective Observational Studies
저자	I Ketut Adi Suryana
출판정보	2026; 2026(1):
키워드	Cardiac intervention, Contrast-induced acute kidney injury, Hydration volume-to weight ratio, risk
초록	Objectives: Contrast-induced acute kidney injury (CI-AKI), a common complication following interventional cardiology procedures, is associated with in-hospital and long-term morbidity and mortality. Although intravenous hydration is the current treatment to prevent CI-AKI, no well-defined protocols exist regarding its optimal rate and duration of administration. This study aimed to investigate the intravascular hydration volume-to-weight (HV/W) ratio for predicting the risk of CI-AKI in patient undergoing cardiac interventions. Methods: This systematic review and meta-analysis were conducted in conformity with the PRISMA 2020 guidelines on four databases for eligible studies up to February 11, 2025. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). Effect sizes were presented as odds ratio (OR) and diagnostic accuracy parameters (sensitivity and specificity). The study protocol has been registered to PROSPERO (ID CRD420251007554). Statistical analyses were conducted using RevMan ver. 5.4 and STATA ver. 17.0. Results: Seven prospective studies involving 9,573 participants undergoing cardiac interventions with low-osmolality contrast agents were included. The overall CI-AKI incidence was 8.89%. With a value of ≥10.21–11.03 ml/kg, HV/W was associated with an increased risk of CI-AKI (OR 2.49 [2.00–3.10]) and could predict CI-AKI with a sensitivity and specificity of 75% and 45%. Meta-regressions showed that the pooled OR was not influenced by other covariates, including sex (p=0.83), age (p=0.95), blood pressure (p=0.59), cardiac function (p=0.77), CHF (p=0.71), Diabetes (p=0.72), anemia (p=0.85), contrast volume (p=0.93) and Mehran score (p=0.91). Conclusion: Higher HV/W is associated with an increased risk of CI-AKI in patients undergoing cardiac interventions. Given the current limitations, future multicenter trials that specifically consider potential effect influencing factors, longer follow-up evaluation, and methodological quality are warranted.
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