대한신장학회

논문분류	춘계학술대회 초록집
제목	Association between Fatty Liver Index and Chronic Kidney Disease on Mortality Risk: A Longitudinal Cohort Study
저자	Jung Eun Lee
출판정보	2026; 2026(1):
키워드	fatty liver index, chronic kidney disease, mortality
초록	Objectives: Both fatty liver disease and chronic kidney disease (CKD) are common metabolic conditions associated with increased mortality risk. However, the combined impact of hepatic steatosis, assessed using the fatty liver index (FLI), and CKD on long-term mortality remains unclear in the general population. Methods: This prospective cohort study included 8,432 participants from the Korean Genome and Epidemiology Study (KoGES). Hepatic steatosis was assessed using FLI and categorized as <30 or ≥30. CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m² or the presence of proteinuria (urine dipstick ≥1+). Participants were classified into four groups based on combined FLI and CKD status. All-cause mortality was ascertained through national death registry linkage. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Subgroup analyses were performed according to sex and diabetes status. Results: During a mean follow-up of 14.95 years, CKD was strongly associated with an increased risk of all-cause mortality regardless of FLI status. In fully adjusted models, participants with CKD had more than a twofold higher mortality risk compared with those without CKD, irrespective of FLI category. Elevated FLI (≥30) in the absence of CKD was also independently associated with increased mortality risk (HR, 1.31; 95% CI, 1.08–1.59). Subgroup analyses showed that the association of elevated FLI with mortality was more pronounced in women and in participants without diabetes, whereas CKD remained the dominant determinant of mortality risk across all subgroups. Conclusion: Both CKD and elevated fatty liver index were independently associated with increased all-cause mortality. CKD conferred the highest mortality risk regardless of hepatic steatosis, while elevated FLI was associated with increased mortality particularly among women and individuals without diabetes. These findings highlight the importance of integrated cardiometabolic risk assessment incorporating both hepatic and renal dysfunction in the general population.
원문(PDF)	PDF 원문보기

간행물 검색

대한신장학회 회원관리 규정