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논문분류	춘계학술대회 초록집
제목	Kidney Function Monitoring in Adult Cancer Patients After Chemotherapy: Incidence and Factors Associated with Kidney Dysfunction
저자	Ining Kartika Tarmidi
출판정보	2026; 2026(1):
키워드	Acute kidney injury, Acute kidney disease, Chronic kidney disease, Chemotherapy, Kidney function monitoring
초록	Objectives: Kidney dysfunction following chemotherapy remains a major clinical challenge. Although acute kidney injury (AKI) is widely recognized, less is known about subacute and longer-term kidney outcomes, particularly in low- and middle-income settings. This study aimed to determine the incidence of AKI, acute kidney disease (AKD), and chronic kidney disease (CKD) following chemotherapy and to identify associated factors. Methods: We conducted a retrospective cohort study of adult cancer patients who received systemic chemotherapy at a tertiary referral hospital in Indonesia between January and December 2024. Patients with available baseline and serial post-chemotherapy serum creatinine measurements were included. AKI, AKD, and CKD were defined according to KDIGO criteria and analysed separately, each compared with patients without kidney dysfunction. Multivariable logistic regression was performed to identify independent associated factors. Results: Among 244 patients, 89 (36.5%) developed kidney dysfunction during follow-up (AKI 10.2%, AKD 15.6%, CKD 10.7%). In multivariable analysis, lower baseline eGFR (AOR 1.18 per 10 mL/min decrease; 95% CI 1.02–1.36) and male sex (AOR 1.76; 95% CI 1.02–3.03) were independently associated with any kidney dysfunction. Subgroup analyses showed that age >60 years (AOR 3.92; 95% CI 1.72–8.97) and carboplatin-based chemotherapy (AOR 3.51; 95% CI 1.47–8.39) were independently associated with AKD, whereas lower baseline eGFR (AOR 1.31 per 10 mL/min decrease; 95% CI 1.12–1.54) was independently associated with CKD. Conclusion: Kidney dysfunction following chemotherapy extends beyond AKI, with AKD representing a substantial burden. Older age and carboplatin exposure were independently associated with AKD, underscoring the need for routine kidney function monitoring beyond the acute phase to facilitate early detection and risk stratification.
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