대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Post-Donation Systolic Blood Pressure Trajectories After Living Kidney Donation and Paired Recipient Outcomes: A Nationwide Prospective Cohort Study from KOTRY
저자	Jeong-Yeun Lee
출판정보	2026; 2026(1):
키워드	kidney transplantation, living donor, blood pressure, recipient
초록	Objectives: Post-donation blood pressure changes in living kidney donors may reflect underlying cardiovascular risk, but their impact on paired kidney transplant recipient (KTR) outcomes remains uncertain. Methods: A total of 3,844 living donor–recipient pairs were enrolled from a nationwide multicenter prospective cohort. Longitudinal systolic blood pressure (SBP) measurements of donors after donation were analyzed using latent class mixture modeling to identify SBP trajectories. Donor outcomes and paired recipient outcomes, including incident and uncontrolled hypertension, change in estimated glomerular filtration rate (eGFR), and graft loss were compared. Results: We identified two donor SBP trajectory classes: Class 1 (95.1%), gradual increase; Class 2 (4.9%), steeper increase from a higher baseline. Class 2 donors had significantly higher cumulative incidence of new-onset hypertension and diabetes, and eGFR <60 mL/min/1.73 m² (all p<0.001). Among recipients without pre-transplant hypertension, those of class 2 donors had a higher risk of incident hypertension compared to recipients of class 1 donors (adjusted hazard ratio 2.47; 95% confidence interval 1.31–4.66). In recipients with pre-existing hypertension, donor SBP trajectory was not associated with uncontrolled hypertension; however, recipients of class 2 donors showed a greater decline in eGFR (adjusted β = −0.68; 95% confidence interval −1.08 to −0.27). Graft loss rate did not differ between recipients of two donor SBP trajectories. Conclusion: Distinct post-donation SBP trajectories of living donors were associated with adverse donor outcomes, incident hypertension in KTRs without pretransplant hypertension, and greater eGFR decline in KTRs with pretransplant hypertension. These findings support the clinical importance of longitudinal donor blood pressure monitoring.
원문(PDF)	PDF 원문보기

목록

위로가기