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논문분류	춘계학술대회 초록집
제목	Risk Factors Affecting the Lifetime of Continuous Renal Replacement Therapy Circuits
저자	Jaeseok Kim
출판정보	2026; 2026(1):
키워드	Continuous renal replacement therapy, Circuit, Thrombosis
초록	Objectives: Continuous renal replacement therapy (CRRT) is an essential treatment for critically ill patients with acute kidney injury. Despite appropriate anticoagulation, premature circuit clotting frequently occurs, leading to blood loss, inadequate dialysis delivery, and potentially worse clinical outcomes. This study aimed to identify clinical factors associated with CRRT circuit lifespan. Methods: We retrospectively reviewed the medical records of patients who underwent CRRT at a single center. The primary outcome was the time from CRRT initiation to the first episode of circuit clotting (time to clotting). Clinical variables at CRRT initiation and immediately before the first clotting event were collected. Statistical analyses were performed to determine factors associated with circuit lifespan. Results: A total of 102 critically ill patients and 117 CRRT circuits were included in the analysis. The mean time to clotting was 26.1 ± 18.6 hours. The median blood flow rate and filtration fraction were 120 mL/min and 17%, respectively. Correlation analysis revealed that SOFA score, norepinephrine dose, and corrected calcium level immediately before circuit clotting were significantly associated with time to clotting. In multivariable linear regression analysis, a higher norepinephrine dose (β = −0.267, p = 0.007) and a lower corrected calcium level (β = 0.259, p = 0.009) were independently associated with a shorter CRRT circuit lifespan (Table 1). Conclusion: Higher norepinephrine requirements and lower calcium levels, reflecting greater clinical severity, were independently associated with reduced CRRT circuit survival. These findings suggest that patient hemodynamic instability and metabolic status may play important roles in premature circuit clotting.
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