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논문분류	춘계학술대회 초록집
제목	The Clinical Implication of Visceral-to-Subcutaneous Fat Ratio in Scrub Typhus Patients with Acute Kidney Injury
저자	Ayoung Cho
출판정보	2026; 2026(1):
키워드	scrub typhus, adipose tissue, acute kidney injury
초록	Objectives: Visceral to subcutaneous adipose tissue (VS) ratio is reported to be helpful to predict the development of acute kidney injury (AKI). However, there is no study about the relationship between computed tomography (CT)-measured adiposity and scrub typhus-associated AKI. We aimed to ivestigate whether VS ratio assessed by CT was able to predict the development of AKI in patients with scrub typhus. Methods: Between 2009 and 2024, 683 patients were diagnosed with scrub typhus at Presbyterian Medical Center. Of these, we included 300 patients who underwent CT in our study. Subcutaneous adipose tissue and visceral adipose tissue areas were quantified at the L4-L5 level from abdominal CT scans. We divided the enrolled patients into two groups [low VS ratio (Low-VS, N=146) vs. high VS ratio (High-VS, N=154)] based on the VS ratio of 0.65 and compared clinical characteristics between the two groups. Results: Compared to patients in the Low-VS group, patients in the High-VS group were older (63.1 vs. 63.9 years, P<0.001) and had one or more comorbidities such as hypertension (35% vs. 51%, P=0.017) and diabetes (9.6% vs. 29.2%, P<0.001). The patients in the High-VS group had higher incidence of complications in respiratory and crdiovascular system. Furthermore, AKI developed significantly more in patients in the High-VS group (19.9% vs. 33.1%, P<0.02) as compared to the Low-VS group. The overall incidence of AKI was 26.7%; of which, 18.0%, 7.7%, and 1.0% cases were classified as Risk, Injury, and Failure, respectively. In a multivariate logistic regression analysis for predicting AKI, age, presence hypertension and VS ratio were significant predictors for AKI. Conclusion: The VS ratio is helpful to predict the development of AKI in patient with scrub typhus.
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