대한신장학회

논문분류	춘계학술대회 초록집
제목	Clinicopathological Profile of Native Kidney Biopsies at a Tertiary Referral Center in Indonesia: A Five-Year Retrospective Study
저자	Muh. Dina Tursina Chekmat
출판정보	2026; 2026(1):
키워드	Biopsy, Glomerulonephritis, Glomerulonephritis, Lupus, Glomerulosclerosis, Focal Segmental, Kidney Diseases
초록	Objectives: Native kidney biopsy remains the diagnostic gold standard for glomerular diseases and is essential for therapeutic decision-making. Despite recognized geographic variation in histopathological patterns, contemporary data from Indonesia are limited. This study aimed to describe the clinicopathological spectrum of native kidney biopsies performed at a tertiary referral center over a five-year period. Methods: This retrospective descriptive study included all consecutive native kidney biopsies performed between 2020 and 2025 at Dr. Kariadi General Hospital, Semarang, Indonesia. Demographic characteristics, clinical features, laboratory parameters at the time of biopsy, and histopathological diagnoses were reviewed and summarized descriptively. Transplant biopsies, repeat procedures, and inadequate specimens were excluded. Results: A total of 136 biopsies were analyzed. Patients were predominantly young (mean age 27.1 ± 11.84 years) and female (61.8%), with hypertension present in 55.9%. At biopsy, mean serum albumin was 2.43 ± 0.74 g/dL, serum creatinine 1.6 ± 1.35 mg/dL, blood urea 61.18 ± 51.54 mg/dL, and estimated glomerular filtration rate 78.78 ± 40.61 mL/min/1.73 m². Secondary glomerulonephritis accounted for 67.6% of cases, largely attributable to lupus nephritis, whereas primary glomerulonephritis comprised 32.4%. Proliferative patterns predominated (69.9%), most commonly mesangial proliferative glomerulonephritis (47.1%), followed by diffuse proliferative glomerulonephritis (18.4%). Endocapillary glomerulonephritis (3.7%) and crescentic glomerulonephritis (0.7%). Non-proliferative lesions comprised 16.9%, including minimal change disease (11.8%) and membranous nephropathy (5.1%). Sclerosing lesions accounted for 13.2%, predominantly focal segmental glomerulosclerosis (11.8%), with advanced glomerulosclerosis observed in 1.5%. Conclusion: Secondary glomerulonephritis, driven primarily by lupus nephritis, was the leading biopsy-proven renal disease in this tertiary-care setting and occurred predominantly in young women. The marked predominance of proliferative lesions reflects a substantial burden of immune-mediated kidney injury and emphasizes the central role of kidney biopsy in defining disease distribution and guiding clinical management in Indonesia.
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