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논문분류	춘계학술대회 초록집
제목	The Protective and Synergistic Effect of Healthy Behaviors on the Progression of Coronary Artery Calcification: From the KNOW-CKD Study
저자	Yujung Kim
출판정보	2026; 2026(1):
키워드	healthy behavior, lifestyle modification, coronary artery calcification, chronic kidney disease
초록	Objectives: Healthy lifestyles are known to lower cardiovascular risk in the general population, but their role in CKD (chronic kidney disease) is unclear. CAC (coronary artery calcification) is an important predictor of cardiovascular risk and is more prevalent and severe in patients with CKD than in the general population. However, little is known on the relationship between healthy lifestyle and CAC in CKD patients. The purpose of this study is to examine the relationship between maintenance of healthy behaviors and the progression of CAC in predialysis CKD patients. Methods: This study analyzed 1,039 participants from the KNOW-CKD cohort. The coronary artery calcium score (CACS) was assessed using cardiac computed tomography at baseline and 4 years after enrolment. CAC progression was defined using the Sevrukov method. Participants scored 1 point for each of the 4 healthy behaviors (no abdominal obesity, adequate drinking, no current smoking and health-enhancing physical activity). Participants were classified into 3 groups according to the total points (0-1, bad; 2, moderate; 3-4, good). Results: CAC progression was significantly lower in the better healthy behavior groups (bad vs moderate vs good: 46.9% vs 39.4% vs 32.0%, P = 0.001). In multivariate logistic regression (Model 3), compared with the bad group, the adjusted odds ratio for CAC progression was 0.71 (95% CI: 0.47-1.07) for the moderate group and 0.66 (95% CI: 0.44-0.98) for the good group. Although individual components did not show significant associations, the trend suggested a synergistic protective effect of maintaining multiple healthy behaviors. Conclusion: Maintaining healthy behaviors was associated with reduced risk of CAC progression in CKD and this protective effect was synergistic. (This abstract was also submitted for the APCM-ISPD 2025 congress. By submitting the abstract to KSN 2026, abstract authors declare that re-submitting the abstract is permitted by the organizers of the previous meeting.)
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