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논문분류	춘계학술대회 초록집
제목	Distribution of NT-proBNP (N-terminal pro-brain natriuretic peptide) and Its Association with Sex, Age, and Comorbidities in Hemodialysis Patients: A Retrospective Observational Study
저자	Nurgul Zulpykhar
출판정보	2026; 2026(1):
키워드	NT-proBNP, hemodialysis, cardiovascular risk, sex differences, age
초록	Case Study: Background: NT-proBNP is a direct biomarker of myocardial wall stress and volume overload. Elevated NT-proBNP levels are common in patients with renal failure. In hemodialysis patients, NT-proBNP measurement is critical for cardiovascular risk assessment and clinical management. However, data on NT-proBNP distribution and its association with sex, age, and comorbidities in Mongolian patients remain limited. Objective: To determine the distribution of NT-proBNP and its association with sex, age, and comorbidities in hemodialysis patients. Methods: A retrospective observational study was conducted among 77 hemodialysis patients treated in Mongolia between 2022 and 2026. NT-proBNP levels were obtained from clinical laboratory records. Data distribution, variability, and outliers were assessed using boxplots and Tukey’s hinges. Statistical analyses included median, interquartile range (IQR), mean, and standard deviation (SD). Results: NT-proBNP levels showed high variability and a right-skewed distribution (Mean ± SD: 12,095 ± 11,785 pg/ml; Median [IQR]: 8,155 [2,662–18,102] pg/ml). Male patients had significantly higher NT-proBNP than females (Median [IQR]: 10,140 [5,000–23,859] vs 5,654 [1,490–16,055] pg/ml, p = 0.042). No statistically significant differences were observed across age groups (p = 0.105) or comorbidity groups (p = 0.059), although higher levels were noted in Chronic diffuse glomerulonephritis and diabetic nephropathy subgroups. NT-proBNP levels were not significantly correlated with HGB (rho = -0.088, p = 0.446). Conclusion: NT-proBNP is highly variable and right-skewed among Mongolian hemodialysis patients, with male patients exhibiting significantly higher levels. While differences across age and comorbidity groups were not statistically significant, observed trends suggest clinical relevance for cardiovascular risk stratification. These findings support the utility of NT-proBNP as a biomarker for cardiovascular assessment in hemodialysis patients and highlight the need for larger multicenter studies to explore associations with clinical outcomes.
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