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제목	Concurrent Anti Glomerular Basement Membrane Disease And Immunoglobulin Nephropathy: A Retrospective Study From A Tertiary Care Centre In India
저자	Leelavathi Venkatesh
출판정보	2026; 2026(1):
키워드	Anti Glomerular Basement Membrane Disease, , Immunoglobulin A Nephropathy, Glomerulonephritis.
초록	Objectives: Concurrent Anti‑Glomerular Basement Membrane (Anti‑GBM) disease and Immunoglobulin A (IgA) Nephropathy represent a rare dual‑mediated glomerular injury with limited data from India. This study describes the clinical, histopathological, immunological characteristics and renal outcomes of biopsy‑proven dual‑positive cases. Methods: This retrospective observational study was conducted at the Institute of Nephro-Urology, Bangalore, between 2019 and 2025. Among 70 Anti‑GBM cases, 19 (27.1%) patients demonstrated biopsy‑confirmed coexistence of Anti‑GBM disease and IgA nephropathy. Clinical features, laboratory parameters, immunofluorescence patterns, histopathology, treatment, and outcomes were analysed. Results: Of the 19 patients, 12 (63%) were female with a mean age of 36 years. Rapidly Progressive Glomerulo-Nephritis (RPGN) was the most common presentation among 11 (58%) patients. On light microscopy, crescents were observed in 16 (84%) patients of which 9 (47.3%) patients shown fibro cellular crescent. Interstitial Fibrosis and Tubular Atrophy (IFTA[NR1] ) >50% was noted in 7 (37%) patients. All patients showed mesangial IgA deposition and linear Immunoglobulin G (IgG) along the GBM, with C3 Co‑deposition. Anti‑GBM titers were positive in only 3 (15.7%) patients. Majority of the patients received steroid‑based regimens, with varying use of Cyclophosphamide and Plasmapheresis. Overall, 8 (42%) patient achieved dialysis independence, while 9 (47%) remained dialysis‑dependent. Mortality was observed in 4 (21%) patients. The prognostic triad of Oliguria, Creatinine (≥10 mg/dL) and Crescent Burden (>50%) strongly correlated with poor renal recovery. [NR1]Write the full form and short form in brackets Conclusion: This Six‑year series represents, one of the largest Indian cohorts of concurrent Anti‑GBM disease and IgA Nephropathy. Baseline renal function, Crescent burden and IFTA[NR1] >50% emerged as key predictors of the outcome. Early recognition of high‑risk patients is crucial to optimize therapeutic interventions and improve renal prognosis. [NR1]Write the full form and short form in brackets
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