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논문분류	춘계학술대회 초록집
제목	SGLT2 Inhibitors for Prevention of Contrast-Induced Acute Kidney Injury During Coronary Procedures: A Meta-Analysis of Randomized Controlled Trials
저자	Muhammad Farid Rakhman
출판정보	2026; 2026(1):
키워드	SGLT2 inhibitors, contrast-induced acute kidney injury, coronary angiography, percutaneous coronary intervention, randomized controlled trials
초록	Objectives: CI-AKI remains a common complication of coronary procedures without effective pharmacological prevention. SGLT2 inhibitors have mechanistically plausible renoprotective properties, but their efficacy in randomized trials has not been systematically synthesised. Methods: Systematic review and meta-analysis of RCTs evaluating SGLT2 inhibitors for CI-AKI prevention in patients undergoing coronary procedures. PubMed/MEDLINE, Scopus, Google Scholar, and the WHO ICTRP were searched through February 2026. Primary outcome was CI-AKI incidence; secondary outcomes included serum creatinine and eGFR changes at 48 to 72 hours. Risk of bias was assessed with the Cochrane RoB2 tool. Results: Four RCTs enrolling 685 patients were included. CI-AKI occurred in 5.8% of SGLT2 inhibitor recipients versus 9.8% of controls (RR 0.66, 95% CI 0.34–1.26; p=0.21; I²=20%), a trend that did not reach statistical significance. Serum creatinine change was non-significant (MD −0.24 mg/dL; p=0.18). eGFR was significantly better preserved in the SGLT2 inhibitor group (MD +7.39 mL/min/1.73 m², 95% CI 2.59–12.18; p=0.003). Two trials were at low risk of bias and two at some concerns. Conclusion: SGLT2 inhibitors demonstrated consistent directional benefit and significantly preserved eGFR across all four RCTs, suggesting a genuine renoprotective signal that the current sample was underpowered to confirm through CI-AKI incidence alone. These findings support adequately powered trials in high-risk populations.
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