대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Renal Artery Calcification Is Associated with Accelerated Kidney Function Decline and Adverse Kidney Outcomes in Older Adults
저자	Hyung Eun Son
출판정보	2026; 2026(1):
키워드	renal artery stenosis, CKD, renal outcome, Agatston score, eGFR
초록	Objectives: Renal artery calcification score (RACS), quantified using the Agatston method, reflects renal vascular calcification; however, its association with longitudinal kidney function decline and kidney disease progression remains incompletely understood. We investigated the impact of RACS severity on kidney outcomes in older adults. Methods: This retrospective cohort study included subjects aged 60 years or older who underwent abdominal computed tomography (CT) and had serum creatinine measured at least three times at Chung-Ang University Hospital between January 1, 2005 and February 28, 2020. RACS was calculated using the Agatston scoring method. Patients were categorized into three groups: RACS = 0, and RACS > 0 stratified into low and high groups according to the median RACS value among those with detectable calcification. Annualized change in estimated glomerular filtration rate (ΔeGFR) was assessed. Kidney outcomes included a composite of sustained 40% decline in eGFR or progression to ESRD, as well as each component analyzed separately. Multivariable Cox proportional hazards models were used to estimate adjusted hazard ratios. Results: Among 25,806 participants, annualized eGFR decline differed significantly across RACS groups (median [IQR]: −0.013 [4.56] for RACS = 0, 0.351 [5.56] for RACS > 0 [low], and 0.885 [7.03] mL/min/1.73 m²/year for RACS > 0 [high]; P < 0.001), demonstrating a graded association between RACS severity and kidney function decline. Higher RACS was also associated with progressively increased risk of the composite kidney outcome. Compared with RACS = 0, adjusted hazard ratios were 1.14 (95% CI 1.02–1.27) for low RACS and 1.31 (1.17–1.45) for high RACS. Kaplan–Meier curves showed stepwise separation according to RACS severity (Figure). Conclusion: In older adults, renal artery calcification was independently associated with accelerated kidney function decline and adverse kidney outcomes, demonstrating a clear dose-dependent relationship between RACS severity and kidney disease progression.
원문(PDF)	PDF 원문보기

목록

위로가기