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논문분류	춘계학술대회 초록집
제목	Cases of Propofol-Related Infusion Syndrome Detected During CRRT by Lipemic Clot Formation
저자	Hani Jang
출판정보	2026; 2026(1):
키워드	Propofol-related infusion syndrome, Continuous renal replacement therapy, Hypertriglyceridemia, Lipemic clot formation, Critical care sedation
초록	Case Study: Background: Propofol is widely used for sedation in intensive care units, particularly in surgical ICUs for patients with elevated intracranial pressure or mechanical ventilation. Propofol-related infusion syndrome (PRIS) is a rare but life-threatening complication, typically associated with prolonged infusion and critical illness. There is no established preventive strategy. We report four cases of suspected PRIS identified by lipemic clot formation in continuous renal replacement therapy (CRRT) filters. Case Presentation: Case 1: A 92-year-old woman with intracerebral hemorrhage underwent burr hole trephination and received CRRT for intracranial pressure control. On CRRT day 5, a white clot was observed in the filter. Triglycerides (TG) increased from 125 mg/dL to 885 mg/dL, and AST/ALT rose to 2354/488 U/L. After 7 days of propofol infusion, the drug was discontinued. The patient deteriorated and died 3 days later. Case 2: A 61-year-old woman with subarachnoid hemorrhage underwent coil embolization and CRRT. On CRRT day 4, lipemic clotting was noted with TG 833 mg/dL and AST/ALT 7000/1184 U/L. Propofol was stopped, and the patient gradually improved and was discharged on hospital day 64. Case 3: A 78-year-old man with trauma-induced AKI received CRRT. On day 2, filter abnormalities with elevated TG and liver enzymes were detected. Laboratory findings improved after discontinuation of propofol; however, he later died from ARDS. Case 4: A 68-year-old man with septic AKI developed similar findings on CRRT day 3. Propofol was discontinued promptly, and he recovered. Conclusion: PRIS is a critical condition with significant impact on prognosis. In patients receiving CRRT, visual detection of lipemic clot formation may provide an early clinical clue. Careful monitoring is essential when propofol is administered during CRRT.
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