대한신장학회

논문분류	춘계학술대회 초록집
제목	Sex-Specific Associations of Nutritional and Metabolic Reserves with Frailty in Chronic Kidney Disease
저자	Po-Ya Chang
출판정보	2026; 2026(1):
키워드	Frailty, nutritional status, metabolic reserves, chronic kidney disease
초록	Objectives: Frailty in chronic kidney disease (CKD) is associated with risk of disability and accelerated renal function decline. However, sex differences in frailty risk and the extent to which nutritional and metabolic characteristics contribute to frailty in men and women with CKD remain unclear. This study aimed to evaluate the associations of nutritional and metabolic characteristics with frailty in CKD patients, overall and stratified by sex. Methods: This study included 5,212 patients with CKD from the Taipei Medical University Clinical Research Database between 2008 and 2019. Frailty was quantified using a cumulative deficit–based multimorbidity frailty index (mFI). Deficits were identified using the first three digits of ICD-9 diagnostic codes and were considered present if patients had ≥3 outpatient primary/secondary diagnoses at least 28 days apart or ≥1 inpatient primary diagnosis. Diagnoses with a prevalence >2% were retained as deficit items. The mFI was calculated as the number of deficits present divided by the total number of deficit items. Multivariable logistic regression assessed associations between nutritional/metabolic characteristics and frailty, overall and by sex. Results: The mean age of participants was 62.9 ± 13.3 years, and 44.3% were female. In the overall multivariable model, male was associated with lower odds of frailty (OR 0.800, 95% CI 0.699–0.914), whereas older age was associated with higher odds. Higher serum albumin (OR 0.774, 95% CI 0.693–0.865), total cholesterol (OR 0.995, 95% CI 0.994–0.997), and HbA1c (OR 0.941, 95% CI 0.899–0.986) were inversely associated with frailty. In sex-stratified analyses, albumin and total cholesterol remained inversely associated with frailty in both females and males. HbA1c was inversely associated with frailty in females but not in males. Conclusion: Higher serum albumin and total cholesterol levels were associated with lower odds of frailty among patients with CKD. These findings underscore the importance of nutritional and metabolic profiles while revealing sex-specific associations in frailty.
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