대한신장학회

논문분류	춘계학술대회 초록집
제목	Long-term Impact of Regular Intravenous Nutrient Therapy (Fursultiamine, Placental Extract, Glutathione, and Glycyrrhizin) on Renal Function and Nutritional Status: A 1-Year Retrospective Study Including a CKD Subgroup
저자	Heeryong Lee
출판정보	2026; 2026(1):
키워드	Intravenous Nutrient Therapy, Renal Safety, Nutritional Status, Chronic Kidney Disease, Hemoglobin
초록	Objectives: Intravenous nutrient therapy (IVNT)—commonly comprising fursultiamine ("garlic"), human placental extract, glutathione ("jade"), and glycyrrhizin ("licorice" injections)—is widely used in real-world practice for fatigue recovery. However, long-term safety data regarding its impact on renal function, especially in patients with underlying chronic kidney disease (CKD), remain scarce. This study evaluated the 1-year safety profile and nutritional benefits of this specific IVNT combination. Methods: We retrospectively analyzed 35 patients who received regular IVNT (fursultiamine, placental extract, glutathione, and glycyrrhizin) at 1-2 month intervals for over a year. Renal (eGFR, Cr) and nutritional (Hb, Albumin) parameters were evaluated at baseline and after 1 year. Individual changes (Delta = Post - Pre) were analyzed using the Wilcoxon signed-rank test. A subgroup analysis was performed on patients with baseline eGFR <= 60 mL/min/1.73m² (n=7) to assess the risk of renal deterioration. Results: In the overall cohort, the mean eGFR delta was +0.56±7.97 mL/min/1.73m², with 60.0% of patients showing maintained or improved eGFR (p=0.588). Notably, in the CKD subgroup (n=7), renal function did not deteriorate; rather, mean eGFR increased from 41.83 to 46.64 (Delta +4.81, p=0.219), and serum Cr decreased from 1.86 to 1.69 mg/dL (Delta -0.17, p=0.109). Regarding nutritional status, the mean hemoglobin delta was +0.41±0.78 g/dL. 80.0% of the total patients exhibited maintained or elevated Hb levels, demonstrating a statistically significant improvement (p=0.002). Conclusion: Long-term regular administration of fursultiamine, placental extract, glutathione, and glycyrrhizin demonstrated an excellent renal safety profile without aggravating kidney function, even in high-risk patients with baseline CKD stage 3 or higher. Furthermore, the significant elevation in hemoglobin levels suggests that this IVNT combination substantially contributes to overall nutritional improvement.
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