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논문분류	춘계학술대회 초록집
제목	Combined Association of Serum Uric Acid and High-Sensitivity C-Reactive Protein with Chronic Kidney Disease Prevalence: A Nationwide Population-Based Study
저자	Hyunglae Kim
출판정보	2026; 2026(1):
키워드	Chronic kidney disease, Uric acid, C-reatctive protein, Inflammation, KNHANES
초록	Objectives: Chronic kidney disease (CKD) is a major public health burden. While serum uric acid (UA) and high-sensitivity C-reactive protein (hsCRP) are known individual predictors of renal impairment, their combined effect on CKD remains underexplored. This study aimed to examine the independent and combined associations of serum UA and hsCRP with CKD prevalence in the general population. Methods: We analyzed data from 9,116 adults (aged ≥19 years) using the Korea National Health and Nutrition Examination Survey 2022–2023. Participants were categorized into four groups based on highest quartile cutoffs for UA (≥5.9 mg/dL) and hsCRP (≥1.1 mg/L): Low-Low, Low-High, High-Low, and High-High. CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73m² or a urine albumin-to-creatinine ratio ≥30 mg/g. Adjusted odds ratios (aORs) were calculated using multivariable logistic regression. Results: Elevated UA and hsCRP were independently associated with CKD. When combined, the odds of prevalent CKD increased progressively. Compared with the Low-Low reference group, the High-High group exhibited the highest odds of CKD (aOR, 2.60; 95% confidence interval, 1.87–3.61). In subgroup analyses, this combined association was significantly more pronounced in older adults (≥65 years), women, and individuals with pre-existing hypertension or dyslipidemia (all P for interaction < 0.05). Conclusion: The concomitant elevation of serum UA and hsCRP is cumulatively associated with a higher prevalence of CKD, reflecting a significant interplay between metabolic and inflammatory pathways. Integrative monitoring of both biomarkers may facilitate early identification of individuals with increased likelihood of CKD and support targeted preventive strategies.
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