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논문분류	춘계학술대회 초록집
제목	Discontinuation of Chronic Kidney Disease Clinical Studies: A Cross-Sectional Analysis
저자	Yousef Radwan Alnomani
출판정보	2026; 2026(1):
키워드	Chronic Kidney Disease, Clinical Trials, Trials Discontinuation
초록	Objectives: Clinical studies on chronic kidney disease (CKD) are vulnerable to discontinuation and non-publication, representing significant sources of research waste in clinical medicine. This study evaluates the characteristics of clinical studies on CKD to identify the reasons behind early discontinuation and non-publication, aiming to prevent these issues in the future. Methods: We searched ClinicalTrials.gov for all clinical studies related to CKD up to February 2026. Data on enrollment, study location, Funder type, and study type were extracted and analyzed using binomial logistic regression. Results: A total of 3,639 eligible registered clinical studies were included in the analysis. Of these, 3,117 (85.7%) were completed, and 522 (14.3%) were discontinued. Unadjusted logistic regression analysis identified several significant predictors: - Studies with small sample sizes (fewer than 100 participants) were significantly more likely to be discontinued (OR = 0.30, 95% CI [0.23–0.40], P < 0.001). - Studies conducted at a single location were more likely to be completed than those conducted at multiple locations (OR = 1.45, 95% CI [1.13–1.86], P = 0.004). - Intervention studies were more likely to be discontinued than observational studies (OR = 0.61, 95% CI [0.39–0.94], P = 0.026). - There was no significant difference between industrial and non-industrial funding studies (OR = 1.17, 95% CI [0.90–1.53], P = 0.25). Conclusion: A substantial proportion of CKD clinical studies are discontinued before completion, contributing to research waste and delayed scientific progress. Our findings indicate that smaller sample sizes, multi-site designs, and interventional study types are associated with a higher likelihood of discontinuation, while funding source does not appear to significantly influence study completion. These results highlight the importance of realistic recruitment planning, efficient study design, and strengthened coordination across study sites to improve trial completion rates. Addressing these challenges may reduce research waste and enhance the efficiency and impact of CKD clinical research.
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