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논문분류	춘계학술대회 초록집
제목	Comparison of Clinical Features and Outcomes in Peritoneal Dialysis-Associated Peritonitis Patients With and Without Diabetes: A Multicenter Retrospective Cohort Study
저자	Lingfei Meng
출판정보	2026; 2026(1):
키워드	Diabetes mellitus, Technical failure, Mortality, Peritoneal dialysis, Peritoneal dialysis-associated peritonitis
초록	Objectives: To compare the clinical features and outcomes of PDAP between patients with DM and those without. Methods: In this multicenter retrospective cohort study, we enrolled patients who had at least one episode of PDAP during the study period. The patients were followed for a median of 31.1 mo. They were divided into a DM group and a non-DM group. Clinical features, therapeutic outcomes, and long-term prognostic outcomes were compared between the two groups. Risk factors associated with therapeutic outcomes of PDAP were analyzed using multivariable logistic regression. A Cox proportional hazards model was constructed to examine the influence of DM on patient survival and incidence of technical failure. Results: Overall, 373 episodes occurred in the DM group (n = 214) and 692 episodes occurred in the non-DM group (n = 395). The rates of abdominal pain and fever were similar in the two groups (P > 0.05). The DM group had more infections with coagulase-negative Staphylococcus and less infections with Escherichia coli (E. coli) as compared to the non-DM group (P < 0.05). Multivariate logistic regression analysis revealed no association between the presence of diabetes and rates of complete cure, catheter removal, PDAP-related death, or relapse of PDAP (P > 0.05). Patients in the DM group were older and had a higher burden of cardiovascular disease, with lower level of serum albumin, but a higher estimated glomerular filtration rate (P < 0.05). Cox proportional hazards model confirmed that the presence of diabetes was a significant predictor of all-cause mortality (hazard ratio = 1.531, 95% confidence interval: 1.091-2.148, P < 0.05), but did not predict the occurrence of technical failure (P > 0.05). Conclusion: Diabetes is associated with higher all-cause mortality but not therapeutic outcomes of PDAP.
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