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논문분류	춘계학술대회 초록집
제목	In Vivo Evidence of p-Cresyl Sulfate-Induced Neointimal Hyperplasia in a Murine Model
저자	Shina Lee
출판정보	2026; 2026(1):
키워드	hemodialysis, p cresyl sulfate, uremic toxin, vascualr access
초록	Objectives: Vascular access failure remains a major cause of morbidity in hemodialysis patients, primarily driven by smooth muscle cell (SMC) proliferation-related neointimal hyperplasia. The uremic toxin p-cresyl sulfate (p-CS) has been implicated in poor vascular access outcomes. Extending our previous ex vivo findings, this study aimed to demonstrate the direct role of p-CS in inducing neointimal hyperplasia in vivo using a murine model. Methods: C57BL/6 mice underwent either a subtotal nephrectomy (1/2 Nx) or a sham operation at 8 weeks of age. Subsequently, the mice received intraperitoneal injections of p-CS for 4 weeks, after which they were sacrificed. The extent of neointimal hyperplasia in the thoracoabdominal aorta was then assessed. The mice were assigned to the following groups: sham (n = 7), 1/2 Nx + p-CS (n = 10), 1/2 Nx + p-CS + N-acetylcysteine (NAC) (n = 8), 1/2 Nx + p-CS + probenecid (n = 8), and 1/2 Nx + probenecid (n = 8). Results: The cross-sectional area of neointimal hyperplasia in the thoracoabdominal aorta was significantly larger in the 1/2 Nx + p-CS group compared to the sham control group. Notably, concurrent treatment with either NAC or probenecid effectively prevented this p-CS-induced neointimal expansion. Conclusion: Our in vivo findings confirm that p-CS directly induces neointimal hyperplasia. Further studies are warranted to explore the clinical implications of targeting p-CS to prevent vascular access dysfunction.
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