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논문분류	추계학술대회 초록집
제목	복막 집단전이의 역학
저자	최기철
출판정보	1991; 1991(0):
키워드	N/A
초록	In this article I describe the characteristics of per- toneal barrier exchange in terms of a three-pore model of membrane permselectivity. The peritoneal membrane is then simulated to have a large number of small pores of radius 40-55 A, a small number of large pore of radius 200-300 A and an abundance of transcellular pores of radius 4-5 A. According to this model, solutes < 25 A in radius were found to be permeating across the peritoneal membrane mam ly by means of diffusion across the small pores, where as solutes larger than 40 A were found to reach the peritoneal cavity exclusively by unidiretional convection through the large pores. In addition, water was simulated to be partly tran- sported through the transcellular ultrapores which are not accessible to hydrophilic solute permeation. Small solute absorption from the peritoneal cavity was found to occur by diffusion across small pores. However, molecules larger than 30 A in radius (Mol. Weight > 30, 000) seemed to be absorbed from the peritoneal cavity exclusively via non-size-selective lymphatic drainage. Applying the three-pore model to literature peritoneal equilibriation test (PET) data, solute mass transfer area coefficient (PS) appeared to be higher during the first 30 minutes of dwell time than subsequently. Reductions in solute PS-values with dwell time are explained in terms of a progressively increasing impact of interstitial un- stirred layers on small solute permeation over the course of the cycle.
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