대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Utility of Blood Tests to Predict Upper Gastrointestinal Lesions in Patients with Chronic Kidney Disease
저자	Yoo A Choi, Jung Eun Lee, Kyung Jin Yun, Sang Ju Lee, Yoon Kyung Chang,Chul Woo Yang, Suk Young Kim, Hyeon Seok Hwang
출판정보	2013; 2013(1):
키워드	만성신부전, 빈혈, 철결핍, 내시경/Chronic kidney disease, Anemia, Iron deficiency, Endoscopy
초록	Objective: Anemia and iron deficiency are common complications in patients with chronic kidney disease (CKD). However, information about the diagnostic indicators of bleeding-related upper-gastrointestinal (GI) lesions is sparse and few studies have investigated anemic upper-GI lesions. Methods: We included 165 anemic patients with nondialysis-dependent CKD stages 3-5 (44 patients at stage 3, 52 patients at stage 4, and 69 patients at stage 5). Transferrin saturation (TSAT), serum ferritin, mean corpuscular volume (MCV), and corrected reticulocyte count data were collected to evaluate their diagnostic utility for bleedingrelated upper-GI lesions, which were identified by esophagogastroduodenoscopy. Results: Bleeding-related GI lesions were found in 57 (34.5%) patients. The area under the receiver-operating characteristic curve used to predict bleeding-related lesions was 0.63 for TSAT (p=0.007) and the best cutoff value was 19.7% (sensitivity, 0.53; specificity, 0.76). The combination of cutoffs TSAT <20% or serum ferritin <100 ng/mL produced a 17% increment in sensitivity compared with that of TSAT <20% alone. The corrected reticulocyte levels and MCV had no significant diagnostic utility. In patients with CKD stage 5, the sensitivity of TSAT or its combination with serum ferritin was significantly lower than in patients with CKD stage 3 (all P< 0.05). Conclusions: TSAT is a significant predictor of anemic lesions in the upper-GI tract and serum ferritin can increase the sensitivity of TSAT. However, these indicators should be used with caution in patients with CKD stage 5 because their sensitivity is poor in this context.
원문(PDF)	PDF 원문보기

목록

위로가기