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제목	Brachial-ankle Pulse Wave Velocity Predicts Decline in Renal Function and Cardiovascular Events in Early Stages of Chronic Kidney Disease
저자	Sung Jun Kim, Hye Eun Yoon, Eun Sil Koh, Sungjin Chung, Cheol Whee Park,Chul Woo Yang, Yong-Soo Kim, Seok Joon Shin
출판정보	2013; 2013(1):
키워드	동맥 경직도, 심혈관 질환, 만성신부전/Arterial stiffness, Cardiovascular disease, Chronic kidney disease
초록	Aim: In this study, we investigated the predictive capacity of the brachial-ankle aortic pulse wave velocity (baPWV), a marker of arterial stiffness, for the decline in renal function and for cardiovascular events in the early stages of chronic kidney disease (CKD). Methods: Two hundred forty-one patients who underwent a comprehensive check-up were included and were divided into two groups according to their estimated glomerular filtration rates (eGFR): patients with CKD stages 2 and 3 (30≤eGFR<90 ml/min/1.73m2, the eGFR<0 group; n=117) and those with eGFR≥90 ml/min/1.73m2 (eGFR≥90 group; n=124). The change in renal function, the eGFR change, was determined by the slope of eGFR against time. We analysed whether baPWV was associated with eGFR change or predicted cardiovascular events. Results: baPWV was independently associated with eGFR change in a multivariate analysis of the total patients (β= -0.011, p=0.011) and remained significantly associated with eGFR change in a subgroup analysis of the eGFR <90 group (β=-0.008, p=0.028). baPWV was independently associated with cardiovascular events (odds ratio=1.002, p= 0.048) in the eGFR<90 group, but not in the eGFR≥90 group. The receiver operative characteristic curve analysis showed that 1,568 cm/sec was the cut-off value of baPWV for predicting CV events in the eGFR<90 group (area under curve=0.691, p=0.03) Conclusions: In patients with early stages of CKD, baPWV was independently associated with the decline in renal function and short-term cardiovascular events.
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