대한신장학회

논문분류	춘계학술대회 초록집
제목	Hepatic Manifestations According to Total Liver Volume in Autosomal Dominant Polycystic Kidney Disease
저자	Hyunsuk Kim1, Hayne Cho Park1, Hyunhwa Jang1, Miyeun Han1, Hyung Ah Jo1,Jong Cheol Jeong2, Jaeseok Yang2, Kook-Hwan Oh1, Yongho Song3,Jin Wook Chung3, Young-Hwan Hwang4, Curie Ahn1
출판정보	2013; 2013(1):
키워드	우성다낭신, 간비대, 증상, 합병증, 간부피/ADPKD, Hepatomegaly, Symptoms, Complications, Liver volume
초록	Background: Polycystic liver in autosomal dominant polycystic kidney disease (ADPKD) is often asymptomatic. However, it occasionally results in serious morbidity and mortality. We investigated the prevalence of hepatic symptoms and complications according to height-adjusted total liver volume (htTLV) in ADPKD patients. Method: We conducted a cross-sectional study of 468 subjects who underwent regular follow-up in an ADPKD clinic, including biennial abdominal computed tomography (CT) scans at Seoul National University Hospital between January 2009 and September 2012. We evaluated chronic symptoms related to hepatic cysts by questionnaire and identified complications by medical record review. TLV was measured by stereotactic volumetry using CT and adjusted by the height. The frequency of polycystic liver-related symptoms and complications were evaluated according to the htTLV (group 1>1,800 ml/m vs. group2<1,800 ml/m). Result: The prevalence of polycystic liver was 85.8% in male, 93.1% in female. In subjects older than 40, htTLV was significantly greater in female than male (female 1425±1306, male 1074±439 p<0.001). Group 1 (n=53) was older (56.9±7.7 vs. 50.6±13.1, p<0.001), had higher female proportion (79.6% vs. 51%, p<0.001) and lower mean estimated GFR (47.7±26.2 vs. 58.9±29.5 ml/min/1.73m2, p<0.001) than group 2 (n=415). The most common symptom was back pain (31.9%) followed by abdominal pain (29.2%). Group 1 had a higher prevalence of palpable mass (54.5% vs. 21.8%, p=0.001), nausea and vomiting (22.7% vs. 5.3%, p=0.03), anorexia (18.2%, vs. 5.3%, p=0.024) than group 2. In addition, the prevalence of any complication (83% vs. 33.9%, p<0.001), ascites (49% vs. 11.1%, p<0.001), hemorrhagic cysts (36.7% vs. 14.9%, p<0.001), cyst infection (8.2% vs. 2.0%, p=0.010), hernia (12.2% vs. 2.2%, p<0.001) and biliary dilatation (4.1% vs. 0.5%, p<0.001) was significantly higher in group 1 compared with that in group 2. Conclusion: The frequency of hepatic symptoms and complications is significantly increased in ADPKD patients with htTLV >1,800 ml/m.
원문(PDF)	PDF 원문보기

간행물 검색

대한신장학회 회원관리 규정