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논문분류	춘계학술대회 초록집
제목	Colchicine Ameliorates Renal Apoptosis in Unilateral Obstructive Uropathy
저자	Sejoong Kim1, Jeonghwan Lee2, Nam Ju Heo2, Ki Young Na1, Jin Suk Han2
출판정보	2013; 2013(1):
키워드	콜키친, 자멸사, 섬유화/Colchicine, Apoptosis, Fibrosis
초록	Introduction and Aims: In the kidney with unilateral ureteral obstruction (UUO), alteration of cytoskeleton can induce apoptosis. Colchicine, which inhibits microtubule polymerization, may reduce tissue injury. However, the effect of colchine on renal apoptosis in UUO has not been explored. Methods: UUO was induced in C57BL/6 mice and colchicine (60 μg/kg, intraperitoneally, everyday) or vehicle was administered for 7 days. Results: UUO mice showed increased alpha-tubulin and renal apoptosis. Colchine inhibited the expression of alphatubulin and decreased renal apoptosis 7 days after UUO. In colchicines treated UUO mice, the expression of phophoglycogen synthase kinase-3β and phospho-p38-mitogen-activated protein kinase was decreased, while the expression of Akt and B-cell lymphoma-extra large was increased. Caspase-9 expression was also decreased. Interstitial fibrosis scores on Masson's trichrome stain were not different between vehicle and colchicines treated UUO mice. Expression of alpha-smooth muscle actin, vimentin, collagen type 4 and fibronectin was not different between the two groups. Conclusions: These data suggest that colchicine may have anti-apoptotic effect but lack of anti-fibrotic effect on obstructive kidney models.
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