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논문분류	춘계학술대회 초록집
제목	The Association of Glucose Variability with Diabetic Complication in Korean Diabetic Patients
저자	Mi Jin Lee1, Hye Suk Min1, Jin Joo Cha1, Hye Kyoung Song1, Mi Hwa Lee1,Jung Eun Kim1, Young Youl Hyun3, Nan Hee Kim2, Dae Ryong Cha1, Young Sun Kang1
출판정보	2013; 2013(1):
키워드	혈당 변동성, 당뇨 합병증/Glycemic variability, Diabetic complication
초록	Tight glycemic control lowers the risk of diabetic complications, but it is uncertain that glycemic variability influences diabetic complications. We examined the associations of plasma glucose variability with diabetic complications in a prospective cohort of 161 Korean diabetic patients from 2002 to 2013. Intra-personal mean and standard deviation(SD) of fasting plasma glucose calculated. Also we calculated percent coefficient of variation (%CV= 100X SD/mean). Over the duration of 11 years follow up, diabetic retinopathy and neuropathy, nephropathy developed 14%, 9%, 9.9% of patients compared to start of study. Patients who had retinopathy until the end of study, had higher percentage of coefficient of variation (23.25±10.31 vs 18.46±9.40, p=0.005) than patients without retinopathy. Patients who had neuropathy, nephropathy until the end of study, had higher percentage of coefficient of variation (25.56± 10.73 vs 18.15±8.74, p<0.001, 24.08±10.77 vs 18.12±8.66, p<0.001) than patients without neuropathy, nephroapthy. Also patients who progressed to cerebrovascular disease had higher percentage of coefficient of variation (27.94± 12.09 vs 20.34±9.34, p=0.014) than non-progressor. Taken together, long-term glycemic variability was association with diabetic complication.
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