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논문분류	춘계학술대회 초록집
제목	Urinary Biomarker TIMP-2 Predicts adverse outcomes in patients with Acute Kidney Injury
저자	Sungyoon Lim* 1, Hee Young Lee1, Yoon Suk Go1, Jihyun Yang1, Young Joo Na1, Sang-Kyung Jo1, Won-Yong Cho1
출판정보	2016; 2016(1):
키워드	acute kidney injury, IGFBP7, TIMP-2 , Urinary Biomarker
초록	Background: Several recent studies have shown that insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP2) is a promising biomarker for the early detection of acute kidney injury (AKI), but the role of IGFBP7 and TIMP2 in predicting adverse clinical outcomes has not been well addressed. The purpose of this study was to evaluate the usefulness of urine IGFBP7 and TIMP2 as outcome predictor in patients with AKI. Methods: This was a prospective cohort study enrolling established AKI patients. Urinary biomarkers, including IGFBP7, TIMP2 and NGAL were determined on admission and discharge from hospital. The primary clinical outcome variables were renal replacement therapy (RRT), renal recovery and in-hospital mortality. Results: Initial plasma creatinine concentrations and urinary biomarkers at AKI diagnosis were significantly higher in the RRT group than in the non-RRT group (Creatinine 5.17±3.59 vs 2.98±1.60 mg/dL; NGAL 2035.44±2431.73 vs 880.54±1413.68; IGFBP7 47.67±46.44 vs 33.23±44.55; TIMP2 24.27±45.60 vs 9.58±14.48 ng/mg creatinine, P<0.05). For predicting RRT requirement, increased plasma creatinine and TIMP2 was independently associated with greater odds of RRT in multiple logistic regression analysis. (odds ratio 1.77, P= 0.048; 48.30, P= 0.04, respectively) However, plasma creatinine and urinary biomarkers did not show statistically significant difference and could not predict recovery and the death in this study. Conclusion: This prospective observational study could suggest that Urinary TIMP2 might be served as a strong predictor for the need for the renal replacement therapy early in the course of AKI.
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