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논문분류	춘계학술대회 초록집
제목	Comparison of the Cockcroft-Gault, Modification of Diet in Renal Disease, and the Chronic Kidney Disease Epidemiology Collaboration equations in cancer patients receiving cisplatin-based chemotherapy
저자	So Mi Kim* 1, Hyun Woo Kim2, Changhyun Park1, Eun Kyoung Lee1, Jong Tae Cho1
출판정보	2016; 2016(1):
키워드	cisplatin, glomerular filtration rate, Cockcroft-Gault equation, Modification of Diet in Renal Disease equation, Chronic Kidney Disease Epidemiology Collaboration equation,
초록	Background: Although the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has been recommended for accurate estimated glomerular filtration rate (eGFR), there is little information about comparison of GFR, using Cockcroft-Gault (CG) or Modification of Diet in Renal Disease (MDRD) equations in Asian cancer patients. We investigated the discrepancies in GFR and toxicities, using CG, MDRD and CKD-EPI equations in patients with cisplatin-based chemotherapy. Methods: A total of 229 patients were retrospectively recruited. eGFR using the three equations classified into three categories with GFR < 10 (group A), 10-50 (group B), and > 50 (group C) mL/min. Data were also sorted by the five stages of chronic kidney disease (CKD). Clinical variables were also evaluated. Results: The mean eGFR using the CKD-EPI was the highest among the three equations. Estimations using the MDRD and CKD-EPI resulted in reclassifying 42 (71.2%) and 47 (79.7%), respectively, of 59 patients with group B using the CG into group C. Furthermore, 5 (29.4%) of 17 patients with group B using the MDRD were reclassified into group C using the CKD-EPI. With respect to CKD stage, the MDRD and CKD-EPI resulted in reclassifying 56 (57.1%) and 64 (65.3%), respectively, of 98 patients with stage 3 as determined by the CG into stage 1 or 2. Conclusion: The CG and MDRD equations underestimated GFR as compared to the CKD-EPI equation. Therefore, GFR estimated using the CG or MDRD equations could lead to administration of insufficient doses of chemotherapeutic agents, including cisplatin, to Asian cancer patients.
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