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논문분류	춘계학술대회 초록집
제목	The effect of Resveratrol on the Vascular Renin-Angiotensin-System in Aging Mice
저자	Hye Eun Yoon* 1, Eun Nim Kim1, Min Young Kim1, Ji Hee Lim1, In-Ae Jang1, Tae Hyun Ban1, Seok Joon Shin1, Cheol Whee Park1, Yoon Sik Chang1, Bum Soon Choi1
출판정보	2016; 2016(1):
키워드	aorta, arterial aging , inflammation, oxidative stress, Renin-angiotensin system, Resveratrol
초록	Background: Aging is a major risk factor of cardiovascular disease and the renin-angiotensin system (RAS) is the key player in cardiovascular diseases. Resveratrol is known to have protective effects on inflammation and oxidative stress. This study evaluated the effect of resveratrol on arterial aging and the vascular RAS in mice. Methods: Histologic changes and expressions of collagen IV, fibronectin, angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), prorenin receptor (PRR), Mas receptor (MasR), and superoxide dismutase 1 and 2 (SOD1 and SOD2), were measured in the thoracic aortas from 24-month-old C57/BL6 mice with or without resveratrol treatment. Results: The aorta media thickness significantly decreased in the resveratrol-treated mice compared to the control mice (77.07±15.90 μm vs. 95.20±18.55 μm, P < 0.001). The aortic expressions of collagen IV and fibronectin decreased in the resveratrol-treated mice compared with the control mice. Resveratrol treatment decreased the aortic expressions of AT1R and PRR, and increased those of AT2R and MasR. The expressions of SOD1 and SOD2 increased with resveratrol treatment. Conclusion: The results suggest that resveratrol has protective effects on arterial aging by amelioration of oxidative stress and inflammation, which was associated with the reduction in the PRR-AT1R axis and enhancement of the ATR2-MasR axis.
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