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논문분류	춘계학술대회 초록집
제목	The spectrum of renal histopathology in elderly Korean with renal diseases
저자	Yong Un Kang* 1, Eun Hui Bae1, Seong Kwon Ma1, Soo Wan Kim1
출판정보	2016; 2016(1):
키워드	aged, epidemiology, kidney biopsy, Korean
초록	Background: Studies on biopsy-proven renal disease in the elderly are extremely limited in Korea. This study aimed to investigate the spectrum of renal histopathology and their clinical manifestations in elderly patients undergoing renal biopsy. Methods: All native renal biopsies (n=99) performed in patients aged ≥65 years from January 2004 to December 2015 were retrospectively analyzed. The results were compared with a control group of 1,045 patients aged <65 years receiving renal biopsy during the same period. Results: The number of the elderly was 99 patients with an age of 69.78±4.11 (range 65–81) years at the time of biopsy (men, 55 patients; women, 44 patients). The most common clinical manifestations for renal biopsy was nephrotic syndrome (NS) (44.4%), followed by acute kidney injury (AKI) and NS (17.2%) and AKI (15.2%). Primary glomerular diseases (PGD) (48.5%) occurred more frequently than secondary glomerular diseases (SGD) (41.4%). The most common renal histopathology in PGD was idiopathic membranous nephropathy (iMN, 31.3%), followed by minimal change disease (29.2%), IgA nephropathy (IgAN) (12.5%), and focal segmental glomerulosclerosis (FSGS) (12.5%). Diabetic nephropathy (26.8%) was the most common SGD, followed by hepatitis virus related glomerulonephritis (19.5%), lupus nephritis (LN) (14.6%) and ANCA-associated vasculitis (AAV) (12.2%). When compared with the control group, the results showed that iMN (P<0.0001), FSGS (P=0.021), AAV (P<0.004) and multiple myeloma (P<0.001) occurred more frequently and IgAN (P<0.001) and LN (P<0.001) occurred less frequently in the elderly. Conclusion: These datas indicate that their clinical manifestations and histopathology differ between elderly and non-elderly Korean with renal diseases. Our data are an important contribution to the epidemiology of renal disease in elderly Korean.
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