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논문분류	춘계학술대회 초록집
제목	Clinical Outcomes of BK Virus Associated Nephropathy in Kidney Transplant Recipients
저자	Woo Yeong Park* 1, 2, Hayeon Park1, 2, Yaerim Kim1, 2, Sang Mok Yeo1, 2, Seong Sik Kang1, 2, Kyubok Jin1, 2, Sung Bae Park1, 2, Jeongah So3, Seungyeup Han1, 2
출판정보	2016; 2016(1):
키워드	BK Virus, Graft Survival, Kidney Transplantation, Nephropathy
초록	Background: BK virus-associated nephropathy (BKVN) is an important risk factor causing to be an allograft dysfunction and loss in kidney transplant recipients. Currently, the reduction of immunosuppressant is a general treatment, but a long-term prognosis of BKVN has not been certain. We evaluated clinical outcomes and prognostic factors of graft failure in kidney transplant recipients with BKVN. Methods: We retrospectively analyzed the medical records of 14 kidney transplant recipients diagnosed to BKVN by allograft biopsies in Dongsan medical center from 2001 to 2014. The change of allograft function and graft survivals after BKVN diagnosis were evaluated. Results: Median time from transplantation to BKVN was 6.9 months (range, 4.6 to 8.8) and the follow-up duration after BKVN was 56.6 months (range, 11.3 to 118.2). The mean serum creatinine level and estimated glomerular filtration rate (eGFR) at diagnosis were 2.9 ± 1.3 mg/dL and 45.7 ± 17.3 mL/min/1.73m2. Acute rejection was accompanied in 10 (71.4%) patients at graft biopsies. Graft failure occurred in 8 (57.1%) patients during the follow-up period. The rate of acute rejection at the time of BKVN diagnosis was significantly higher in graft failure group than in non-graft failure group (P=0.015). eGFR at diagnosis was lower in graft failure group than non-graft failure group, but did not differ significantly between the two groups. The degree of change of eGFR before and after BKVN diagnosis showed greater tendency in graft failure group. There were no significant differences according to pathologic stage of BKVN and treatment modalities between the two groups. Conclusion: Clinical outcomes of BKVN were very poor, and especially, BKVN patients combined with acute rejection at the time of BKVN diagnosis progressed to graft failure.
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