| 저자 |
Min Young Seo* 1, kyung Hee Lee1, Kyu Yeun Kim1, Minjung Kim1, Wonseok Do1, Youngae Yang1, Taehoon Yim1, Inryang Hwang1, Sukyung Lee1, Hee-Yeon Jung1, Ji-Young Choi1, Jang-Hee Cho1, Sun-Hee Park1, Yong-Lim Kim1, Chan-Duck Kim1 |
| 초록 |
Background: Kidney transplantation (KT) from older kidney donors has been considered as a solution of organ shortage. We performed detailed analyses about the clinical outcomes of KT from older kidney donors.
Methods: The present study was a retrospective cohort study including patients over 18 years who underwent KT between January 2000 and December 2013 at the Kyungpook National University Hospital. Donors and recipients were categorized by donor type and age. Death-censored graft survival, patient survival and estimated glomerular filtration rate (eGFR) were compared among the groups during the 5 year follow up.
Results: A total of 463 patients, 318 were living donors with 20 older than 60 years and 145 were deceased donor with 110 standard criteria donors (SCD) and 35 extended criteria donors (ECD). Recipients from living donors older than 60 years (90.0%) showed equivalent graft survival compared to recipients from SCD (90.0%), and higher graft survival than recipients from ECD (82.9%). However, the graft survival of recipients from older living donors was lower than that of recipients from younger living donors (91.6%). There was no significant difference in patient survival among the groups. Regardless of donor type, graft survival of older recipients than 60 years from older donors was not significantly different compared to the other patients. Older recipients from older donors revealed the lowest eGFR during the follow-up period.
Conclusion: KT from older living donors showed better or similar graft survival compared to deceased donor KT, although worse than KT from young living donors. Increased donor age could not affect the graft survival after KT. These findings support that older living donors might be an appropriate alternative for the patients waiting deceased donors. |