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논문분류	춘계학술대회 초록집
제목	Evaluation of Circulating Zonulin, Histamine and Diamine Oxidase as Novel Markers of Renal Function
저자	Eun Sil Koh* 1, Min Young Kim1, Hyung Do Cho2, Seok Joon Shin1, Yoon Sik Chang1, Sungjin Chung1
출판정보	2016; 2016(1):
키워드	Albminuria, Diamine oxidase, Glomerular filtration rate, Histamine, Zonulin
초록	Background: Zonulin, a protein that leads to the breakdown of tight gap junctions in the gastrointestinal lining, is associated with intestinal permeability. Histamine balance is also a critical factor in patients with allergic and gastrointestinal symptoms. The aim of the study was to examine whether zonulin, DAO and histamine levels are affected by the amount of albuminuria and estimated glomerular filtration (eGFR) in patients with chronic kidney disease (CKD). Methods: All clinical and laboratory data including measurements of blood zonulin, diamine oxidase (DAO) and histamine concentrations were obtained from 67 patients who admitted for CKD evaluation. The DAO:histamine ratio was calculated to examine balances between DAO and histamine. Results: When controlled for age, sex, body mass index and smoking status, blood DAO level was negatively correlated with eGFR (p=0.003; r=-0.379) while other values were not. In stepwise multiple regression analyses, albuminuria was significantly associated with plasma zonulin level (β=-0.720, p=0.008). Interestingly, dialysis therapy was found to be independently associated with circulating zonulin (β=861.475, p=0.020). Albuminuria (β=-1.259, p=0.002) and eGFR (β=-0.613, p=0.002) exhibited significant inverse associations with circulating DAO level. In addition, albuminuria was related to circulating histamine level (β=0.000, p=0.001) and eGFR was significantly associated with DAO:histamine ratio (β=-3.066, p=0.028). Conclusion: These results demonstrate that circulating zonulin, DAO and histamine levels need to be investigated as potential markers of renal function. Further research is required to explore the nature and causes of these interrelationships.
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