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논문분류	춘계학술대회 초록집
제목	Relationship of serum uric acid and creatinine in acute myeloid leukemia
저자	Abhilash Koratala*, Kawther Alquadan1, Lalitkumar Mundhra1, Abutaleb Ejaz
출판정보	2016; 2016(1):
키워드	Serum creatinine, Serum uric acid
초록	Background: Serum uric acid (SUA) is a predictor of acute kidney injury (AKI) in several clinical states. We therefore investigated the relationship between SUA and renal function in a unique patient cohort wherein SUA levels fluctuate during the course of standard care. Methods: Data from patients undergoing treatment for acute myeloid leukemia (AML) were analyzed retrospectively. Correlations between SUA and serum creatinine (SCr) were investigated. Results: N=126 patients. Baseline SUA was associated with an increased risk for acute kidney injury (AKI; OR 1.27, CI95% 1.1-1.5, p=0.003) and laboratory tumor lysis syndrome (LTLS; OR 1.26, CI95% 1.1-1.5, p=0.005). Significant linear correlations were observed between SUA and SCr (r=0.35, p<0.001) values on day 1 that persisted through day 4. In subgroup analysis, patients with primary AML (r= 0.39, p<0.001) and baseline eGFR >60mL/min/1.73m2 (r= 0.611, p<0.001) demonstrated robust relationships between SUA and SCr. We also observed inverse correlation between SUA and KeGFR on day 1 (r= -0.33, p<0.001) through day 4. Conclusion: The study demonstrated a linear relationship between SUA and SCr and an inverse relationship between SUA and KeGFR. This suggests that SUA-induced renal vasoconstriction is associated with reduced renal blood flow and vascular injury.
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