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논문분류	춘계학술대회 초록집
제목	Renoprotective Effect of Incretin Based Therapies in Aging Kindey
저자	Tae Hyun Ban* 1, In-Ae Jang1, Eun Nim Kim1, Hye Eun Yoon1, Byung Ha Chung1, Cheol Whee Park1, Chul Woo Yang1, Yong-Soo Kim1, Yoon Sik Chang1, Bum Soon Choi1
출판정보	2016; 2016(1):
키워드	aging, Dipeptidyl peptidase-IV, Glucagon-like peptide-1, incretin
초록	Background: The incretin-based agents such as dipeptidyl peptidase IV (DPP-IV) inhibitor and glucagon-like peptide-1 (GLP-1) agonist was associated with diverse protective effect including renoprotective effect except lowering glucose. Aging kidney was characterized by decreased glomerular filtration rate, impaired electrolyte balance, decreased plasma renin activity and histological changes such as glomerulosclerosis and tubular atrophy. We investigated the renal function, albuminuria, the concentration and activity of incretin hormone in serum and urine, and expression of incretin hormone in renal tissue with aging in mice model. Methods: C57BL/6 mice were divided into three groups; 2 months-old (N=8), 12 months-old (N=8), and 24 months-old (N=8). Activities, concentrations and expressions of incretin hormone in serum, urine, and renal tissue were analyzed. Results: According to aging, creatinine clearance and albuminuria were increased (p<0.05, respectively) (Fig. 1). DPP-IV concentrations in serum and DPP-IV activities in renal tissue were gradually increased (p<0.001 and p<0.05, respectively) (Fig. 2 and Fig.3). In analysis of renal tissue, the fractional mesangial area in glomerulus and tubulointerstitial fibrosis were significantly risen with aging (p<0.01, respectively). GLP-1 receptor and DPP-IV protein levels in renal tissue were significantly increased with aging in western blot (p<0.001 and 0<0.05, respectively). Conclusion: It is suggested that incretin based treatment is a possible strategy for preventing an aging process in the kidney. Figures:
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