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논문분류	춘계학술대회 초록집
제목	Comparison of microvascular inflammation in renal allograft tissue between ABO incompatible and ABO compatible kidney transplantation
저자	Eun jeong KO, Bun soom CHOI, Cheol whee PARK, Yong-soo KIM, Chul woo YANG, *Byung ha CHUNG
출판정보	2017; 2017(1):
키워드	ABO-incompatible kidney transplantation, microvascular inflammation
초록	Objectives : Microvascular inflammation (MVI) is considered as a pathological marker for antibody-mediated rejection (AMR) in the presence of donorspecific antibody (DSA). We aimed to investigate clinical role of MVI as predicting AMR in ABO incompatible kidney transplantation. (ABOi KT) Methods : A single-center retrospective matched cohort study was conducted. We evaluated histologic parameters in kidney biopsy of 296/75 ABO compatible (ABOc)/ABO incompatible (ABOi) consecutive living donor KT, matched for donor age and transplantation year. In the ABOi group, the desensitization protocol consisted of rituximab, plasmapheresis and immunoglobulins. Results : Between ABOc and ABOi group, there was no difference in deathcensored graft survival, and patient survival. (p-values for each 0.068. and 0.294) The cumulative incidence of acute rejection determined by both protocol biopsy and indication biospies was 19.5% and 23.2% (p=0.515) There was no difference in the incidence of MVI between ABOi KT and ABOc KT. (p=0.284) The incidence of MVI at protocol biopsy on post KT 3 months were not statistically different between ABOi and ABOc group. (p=0.103) High titer of Anti-A/B antibody didn’t correlated with the risk of MVI. (p=0.689) When compare ABOi KT to human leukocyte antigen (HLA) sensitized KT, highly- HLA-sensitized group (DSA Luminex MFI >5,000 or Pannel reactive antibody (PRA)>50%) showed tendency of increased rejection rate compared to lowsensitized group, despite of statistically insignificance. (p=0.311) And highly sensitized ABOi group had more frequently incidence of MVI than lowsensitized group (p<0.001). Conclusions : In contrast to HLA-DSA, ABO incompatibility or anti-A/B antibody titer was not associated with the development of MVI in allograft tissue.
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