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논문분류	춘계학술대회 초록집
제목	Necro X7 attenuates contrast induced nephropathy.
저자	Jin young JEONG2, Hynsu CHOI5, Young rok HAM1, Hong jin BAE1, Chan hun SONG1, Hae ri KIM1, Wonjung CHOI1, Ki-ryang NA1, Yoon-kyung CHANG3,4, Kang wook LEE1, *Dae eun CHOI1
출판정보	2017; 2017(1):
키워드
초록	Objectives : Major patho-mechanism of contrast induced nephropathy CIN is well known as oxidative stress and osmotic injury of kidney tubules. Although various anti-oxidants are tried in CIN, it has been showed only little effects. NecroX series that can reduce reactive oxygen species and necroptosis pathway. We investigated the effect of NecroX-7 on contrast induced nephropathy (CIN) in mice. Methods : C57BL/6 mice were divided into 4 groups; normal control group, NecroX-7 treated control group ,vehicle with CIN treated group, and NecroX-7 with CIN. CIN mice were prepared by iohexol(1.5 g iodine/kg) injection after ischemia reperfusion renal injury . NecroX-7(2mg/kg) was injected intraperitoneally for 2 days, starting 24 h before surgery. Mice were sacrificed at 24 h after the surgical procedure, and the blood and kidneys were collected. Results : The levels of BUN and serum creatinine in NecroX-7 with contast treated mice were significantly lower than that of vehicle with contrast treated mice(p <0.05). In microscopy, NecroX-7 significantly reduced renal tubular epithelial cell necrosis and detachment in contrast treated mice kidney. Conclusions : NecroX-7 attenuates contrast induced nephrotoxicity.
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