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논문분류	춘계학술대회 초록집
제목	The factors influenced on change in systolic blood pressure variability in Chronic kidney disease patients : the APrODiTe-2 1-year follow-up study
저자	Jiwon RYU1, *Sejoong KIM2, Ran-hui CHA3, Hajeong LEE4, Jung pyo LEE5, Eunjeong KANG4, Young rim SONG6, Yon su KIM4, Sung gyun KIM6
출판정보	2017; 2017(1):
키워드	systolic blood pressure variability, anti-hypertensive drugs, chronic kidney disease patients
초록	Objectives : The blood pressure variability (BPV) may be affected by several factors such as medication, underlying disease and others. We evaluated what factors may influenced change in the BPV in the APrODiTe study in chronic kidney disease(CKD) patients. Methods : We recruited 378 hypertensive CKD patients with 1-year follow-up from 4 centers in Korea. The Systolic BPV (SBPV) was the mean value of the differences between systolic BP at every 30 minutes for 24 hours. The factors were considered anti-hypertensive drugs, diabetes mellitus (DM), smoking, alcohol, exercise, and CKD stages. Results : After 1-year observation period, SBPV were increased by 2.9 mmHg (Initial SBPV, 20.8 ± 11.9 mmHg; final SBPV, 23.7 ± 10.7 mmHg; P < 0.001 by paired t-test). SBPV in patients treated with 2 different anti-hypertensive drugs (renin-angiotensin esterase inhibitor or angiotensin receptor blockers (RAAS blocker) and beta blockers (BB), BB + calcium channel blockers (CCB)) and 3 drugs (RAAS blocker, BB and CCB) sustained over 1-year observation (P = 0.611, P = 0.588 and P = 0.481 by paired t-test, respectively). The type of anti-hypertensive drugs such as RAAS blocker, BB and CCB did not influence on changes in SBPV. In diabetic patients, non-smokers and patients on earlystage CKD (stage 1-2), SBPV was not changed during the observation (P =0.072, P = 0.079 and P = 0.281 by paired t-test, respectively). Conclusions : We found that SBPV in CKD patients may be increased over times, and that multiple anti-hypertensive drug users may prevent the increase in SBPV, rather than the type of anti-hypertensive drugs.
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