대한신장학회

논문분류	춘계학술대회 초록집
제목	Comparison of the urine sodium excretion estimates derived from spot urine and measured 24hr urine sodium in renal disease patients – Correlation analysis according to voiding time
저자	*Yongjin YI, Hayne PARK
출판정보	2017; 2017(1):
키워드	spot urine, sodium intake, urinary excretion of sodium, diurnal variation
초록	Objectives : Measuring salt intake is important for monitoring salt diet in renal disease patients. 24hr urine collection is widely accepted as gold standard method for measurement of sodium intake. Due to burdensome of the 24hr collection, a single collection of spot urine has been studied to supersede 24hr urine sample. However, it is uncertain that which time period of collection is most suite for 24hr urine sodium excretion rate. To find out the best time to estimate 24hr urine sodium excretion, we separately collect urine at every voiding urine and examined simultaneously. Methods : Urine samples were collected over 24 hours in a total of 18 renal disease patients (10 IgAN, 7 nonspecific hematuria, 1 minimal change disease). The patients were asked to record each voiding time and amount of urine. Before putting in a urine bag, each urine specimen was examined separately for 5~10cc. The remaining urine were collected in the urine bag and examined as 24hr urine specimen. We compared measured 24hr urine sodium excretion and estimated daily sodium excretion from each spot urine over the time period. The 24 hours were divided into 6 hour intervals to analyze the correlation between each time period. Estimated sodium excretion in spot urine was derived from sodium (mmol/L)/creatinine (mg/dL) ratio. The value was converted to mg/g, which represents the amount of salt excreted per day. Results : A total of 110 spot urine samples were collected within 18 subjects’ 24hr urine. All urine samples were divided according to time as follows: overnight (12 AM to first morning urine), morning (second morning urine to 12 PM), afternoon (12 PM to 6 PM), evening (6 PM to 12 AM). All subjects were male and mean age was 24.0 ± 6.4 years. Mean height and weight were 175.7 ± 5.1 cm and 74.7 ± 9.1 kg. Average urine excretion rate of creatinine and sodium were 2100 ± 429 mg/day and 3750 ± 1245 mg/day, respectively. Mean level of spot urine sodium/creatinine ratio was 1997 ± 954 mg/g, which value was significantly lower than measured urine sodium excretion (p<0.001). Compared with the measured 24hr sodium excretion, overnight time urine samples showed the highest correlation (r=0.740, p<0.001, pairs n=22). Afternoon (r=0.683, p<0.001, pairs n=41) and evening (r=0.517, p=0.007, pairs n=26) samples also showed high correlation coefficients. First morning urine sample in all subjects similarly showed high correlation with 24hr urine (r=0.739, p<0.001, n=18). The correlation analysis of morning urine (p=0.099, pairs n=21) and second morning urine (p=0.362, n=18) on measured 24hr sodium excretion were not statistically significant. Conclusions : Among the spot urine specimens, the overnight samples before second morning urine showed the highest correlation with the total 24hr measured urine sodium excretion. Most estimates from spot urine were highly correlated with 24hr urine sodium excretion, except urine samples collected from second voiding in morning to 12 PM.
원문(PDF)	PDF 원문보기

간행물 검색

대한신장학회 회원관리 규정