대한신장학회

논문분류	춘계학술대회 초록집
제목	Prediction of the Clinical Outcomes After Deceased Donor Kidney Transplantation Using Kidney Donor Profile Index
저자	Woo yeong PARK1, Ji won MIN2, Young soo KIM3, Bum soon CHOI2, Cheol whee PARK2, Chul woo YANG2, Yong-soo KIM2, Kyubok JIN1, Seungyeop HAN1, *Byung ha CHUNG2
출판정보	2017; 2017(1):
키워드	Kidney transplantation, Risk assessment, Delayed graft function, Graft survival, Patient survival
초록	Objectives : The aim of this study is to investigate the predictive value of Kidney Donor Profile Index (KDPI) for the clinical outcome of deceased donor kidney transplantation (DDKT) in comparison with expanded criteria donor (ECD) or acute kidney injury criteria (AKI) by KDIGO guideline. Methods : Four hundred and twenty four deceased donors and their corresponding 509 KTRs were included from three transplant centers (Seoul St. Mary’s hospital, Keimyung University hospital and Uijeongbu St. Mary’s hospital) in this study. We divided the KTRs into low KDPI group (<68 %) an high KDPI group (>68%) or ECD and SCD group or AKI and non-AKI group according to the status of corresponding donors. We investigated the impact of KDPI, ECD criteria, and AKI by KDIGO guideline on the incidence of delayed graft function (DGF), allograft and patient survivals in KTRs. Results : Two hundred and forty one patients were belonged to high KDPI, and 158 patients were ECD and 303 were AKI group. There were no significant differences in the incidence of DGF between ECD and SCD group or between high KDPI and low KDPI group, but it was significantly higher in the AKI group compared with non-AKI group (P=0.000). In Kaplan-Meier analysis, graft survival rate was significantly higher in low KDPI group than in high KDPI group (Log rank, P=0.017), but no significant differences were detected in the comparison between SCD and ECD group or between AKI and non-AKI group. There were no significant differences in patient survival in all comparisons. In multivariate analysis, high KDPI was an independent risk factor for graft failure after adjusting for age, gender, acute rejection, and DGF (hazard ratio 2.62, 95% confidence interval, 1.29–5.33, P=0.008), but AKI or ECD was not. Conclusions : KDPI did not show significant association with DGF, but it can predict poor graft survival better than the SCD/ECD designation or AKI criteria in DDKT.
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