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논문분류	춘계학술대회 초록집
제목	Improvement of Left Ventricular Diastolic Function after Kidney Transplantation
저자	Kyung sun PARK1, Jongha PARK1, Hyun chul CHUNG1, *Jong soo LEE1
출판정보	2017; 2017(1):
키워드	Kidney transplantation, diastolic dysfunction, E/E`
초록	Objectives : Left ventricular (LV) diastolic dysfunction is frequently observed in patient with end-stage renal disease (ESRD), and has been known as a significant risk factor for cardiovascular events in these patients. We hypothesized that the ratio of early diastolic peak mitral flow velocity to early mitral annulus velocity (E/E`), widely used non-invasive index of LV diastolic dysfunction, would improve following kidney transplantation (KT). Methods : Among patients who received KT at Ulsan University Hospital, 126 KT recipients (73 were female) whose pre- and post-KT echocardiographic findings were available were included this analysis. Linear mixed-effect models with random intercept were used to assess changes in cardiac function and morphology over time after KT. Results : Median duration from KT to post-KT echocardiography (TTE) was 999 days. Mean serum creatinine measured at the time of post-KT TTE was 1.54 mg/dL. Serum level of hemoglobin (P <0.001), phosphorus (P <0.001), and intact parathyroid hormone (PTH, P <0.001) were significantly improved after KT, however the change of body weight was not (64.4 to 62.6kg, P=0.286). In the adjusted model, LV mass index (P=0.044), left atrial volume index (P=0.020) and E/E` (-0.86, 95% CI -1.71 to -0.01, P=0.048) was significantly decreased over time. Conclusions : In addition to cardiac structural abnormality, LV diastolic dysfunction may be successfully improved after KT. Further studies for understanding myocardial pathophysiology after KT may be helpful for improving survival of patients with chronic kidney disease.
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