대한신장학회

논문분류	춘계학술대회 초록집
제목	Association between weight reduction and developing cardiovascular event among the general population
저자	Hae Ryoung Yun1, Hyoungnae Kim1, Seohyun Park1, Jong Hyun Jhee1, Tae Ik Chang2, Jung Tak Park1, Tae-Hyun Yoo1, Shin-Wook Kang1, Seung Hyeok Han1
출판정보	2018; 2018(1):
키워드	Obesity \| Cardiovascular disease \| Body mass index \| Weight reduction \| Metabolic profile
초록	Objectives: Obesity is increasingly prevalent worldwide and has become a growing concern in the general population. Many studies have shown that obesity is a major cause of metabolic diseases and is an important risk factor for cardiovascular disease (CVD). Accordingly, weight reduction has long been considered as a preventive strategy to reduce CV risk in obese individuals. However, it is uncertain whether weight reduction can actually prevent the development of CVD. Methods: Between 2001 and 2002, a total of 10,030 participants were recruited from two cities in Gyeonggi province, Then biannually follow up until 2014. 8,587 participants were included in the analysis after excluding 1,443 participants who met exclusion criteria. Participants were categorized into five group based on quintiles of BMI variation. The primary outcome of interest was composite of CVE, which was defined as the occurrence of MI, CHF, CAD, or CVA during follow-up period. Results: During a mean follow-up duration of 9.5 years, primary outcome occurred in 468 (5.4%) participants; 107 (22.8), 76 (16.2), 109 (23.2), 87 (18.5), and 89 (19.0) across the quintiles, respectively (P = .063). In a multivariable Cox regression after adjustment of confounding factors, the lowest quintile group [median BMI variation -8.3(-10.9 to -6.6) %] had a lower risk of CVE development [HR, 0.493; 95% CI, 0.366-0.663; P<0.001] compared with reference group [median BMI variation -0.5(-1.3 to -0.1) %]. The results showed the consistent association between weight reduction and lower risk of CVD development regardless of whether subjects were obese, overweight, and normal weight. Conclusions: In this study, we showed that weight reduction was significantly associated with decreased risk of developing CVE. This favorable effect of weight reduction can be explained by a decrease in blood pressure and an improvement in metabolic disturbances. This study highlights the importance of weight reduction to prevent CVD.
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